Ganoderma oregonense

Oregon Reishi 

 

Late summer foliage and moss covered trees, follow the lichen and licorice fern trails from the treetops down the trunk and along the fallen logs. In a ravine full of Devil’s club and ground covered in wild ginger, a bright gem appears. The Ganoderma oregonense glows and calls you forward. This mushroom will sometimes share space with G. applanatum and F. pinicola. This annual fruiting body is hard to miss, in its short fruiting season it gets larger than a human head. When its shiny skin is covered in spores it resembles the G. applanatum, it too has a pore surface that bruises. This fruiting body is also often confused with F. pinicola, which does not have a varnished crust and does not bruise on the pore surface.

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Ganoderma oregonense Spagyric.

One drop of Ganoderma Spagyric. It sits in the heart radiating outward across the chest, warming the diaphragm and you can’t help but to smile. The feeling of standing in the forest, dense with life, transformation and decay. Everything is OK, a reminder of the cyclical reality of the earth that is often forgotten. There is always change, there is always death. There is always a breakdown, and with that, a build up. Inspires you to show your bold colors as the Ganoderma does; it’s bright red beauty in a dank forest of browns and greens…such confidence, a reminder that it is Ok to stand out and shine.

 

Distribution

Annual, Summer-Fall

Found on conifers, often Douglas Fir, Pseudotsuga menzeseii, and Hemlock, Tsuga heterophylla.

*Active Known Constituents

• Ganoderic acids
• Various glycans
• 3-oxo-5a-lanosta-8,24-dien-21-oic acid – 3a-acetoxy-5a-lanosta-8,24-dien-21-oic acid ester b-D-glucoside

Spore Print –Brown

 Therapeutic Actions

Anti-­allergenic, anti-­inflammatory, anti-­oxidant, immune-­modulating, immune­‐ stimulating, anti-­viral,Hepato‐ protective, anti­tumor

*There is a lack of research on the Ganoderma oregonense. DNA sequencing of the more extensively researched, G. Tsugae, showed enough similarities to the G. Oregonense¹ that we could postulate the medicinal actions of the latter through the research of the former.

 Medicinal Use

• Triterpenes found in Ganoderma species suppress growth and invasive behavior of cancer cells, whereas the polysaccharides stimulate the immune system.
• These polysaccharides have been termed “Ganopolys”. These Beta-glucans have immune-stimulating, immune-modulating, and anti-tumor activity. These activities correlate with higher molecular weight and lower levels of branching, because these molecules are more water soluble.⁷
• “Ganopolys” affect the body’s immune system by activating macrophage activity, facilitating T- lymphocytes transferring to cytotoxic t cells, and enhancing the amount of B lymphocytes and natural killer cells.⁷
• Triterpenes are bitter components, the bitter flavor conveys a hepatoprotective effect, also stimulates digestive enzyme production by the pancreas, and can help with sugar cravings.
• Hepatoprotective effects were perhaps related to the ability to increase the activity of free radical scavenging enzymes and to raise the ability of antioxidation. Ganoderic acid, one of the triterpenoids found in G. Lucidum, G. Tsugae, G. applanatum, and G. Oregonense, was proven to be a potent inhibitor of β-glucuronidase activity, an indicator of hepatic damage^1,3
• Triterpenoids have high antioxidant activity, and have a cardioprotective effect in mice³
• Activity against 3 cancer cell lines; lanostanoid and a sterol caused death by apoptosis and suggested that is was the sterol that possessed the cell cycle inhibition activity.²
• Aqueous extract showed anti-tumor activity in human breast cancer cells and only showed a cyctotoxic effect on cancer cell lines, no cytotoxic effect found on normal cell lines⁶
• Ganoderma compounds inhibit 5-alpha-keto-reducate activity that is responsible for the biosynthesis of dihydrotestosterone, this indicates a possible therapeutic value in prostate cancer.⁵
• Chitin membrane used as a wound dressing known as sacchachitin and developed from the residue of the fruiting body.^5,8
• A pulpy white residue was tested as a skin substitute, wound healing was found faster than the commercialized skin substitute made from chitin from crab shell. Sacchachitin also showed to have strong antibacterial and antiviral activity.⁵
• Alleviate bronchoalveolar inflammation by decreasing the amount of inflammatory cells and the secretion of inflammatory mediator into the lungs and airways, therapeutic application in allergic asthma.⁹
• Increases oxygen absorbing capacity of alveoli in the lungs

Energetics

Warming, nourishes the heart, disperses stuck energy, tonic, sweet, bitter

Preparation of Dual Extract

See F. pinicola preparation

Work Cited

1. Hong, SG, and HS Jung. “Phylogenetic Analysis of Ganoderma Based on Nearly Complete Mitochondrial Small-subunit Ribosomal DNA Sequences.”National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 03 Mar. 2015.

2. Kuo, Han-Peng, Shih-Chung Hsu, Chien-Chih Ou, Jhy-Wei Li, Hsiu-Hsueh Tseng, Tzu-Chao Chuang, Jah-Yao Liu, Shih-Jung Chen, Muh-Hwan Su, Yung-Chi Cheng, Wei-Yuan Chou, and Ming-Ching Kao. “Ganoderma Tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway.” Evidence-Based Complementary and Alternative Medicine2013 (2013): 1-12. Web

3. KY, Kuok, and Yeh CY. “The Triterpenoids of Ganoderma Tsugae Prevent Stress-induced Myocardial Injury in Mice.” Molecular Nutrition and Food Research57.10 (2013): 1892-896. Web. 25 Mar. 2015.

4. Huang, Chi-Chang, Wen-Ching Huang, Suh-Ching Yang, Chih-Chi Chan, and Wan-Teng Lin. “Ganoderma Tsugae Hepatoprotection against Exhaustive Exercise-Induced Liver Injury in Rats.” Molecules18.2 (2013): 1741-754. Web.

5. Chuang, Chao-ming, HE Wang, and CH Chang. “Sacchachitin, a Novel Chitin-polysaccharide Conjugate Macromolecule Present in Ganoderma Lucidum: Purification, Composition, and Properties.” Pharmaceutical Biology52.1 (2013): 84-95. Web. 25 Mar. 2015

6. Yue, GG, KP Fung, and GM Tse. “Comparative Studies of Various Ganoderma Species and Their Different Parts with Regard to Their Antitumor and Immunomodulating Activities In Vitro.” Journal of Alternative and Complementary Medicine12.8 (2006): 777-89. EBSCO Host. Web. 25 Mar. 2015.

7. Zhou, Xuanwei, Juan Lin, Yizhou Yin, Jingya Zhao, Xiaofen Sun, and Kexuan Tang. “Ganodermataceae: Natural Products and Their Related Pharmacological Functions.” The American Journal of Chinese Medicine35.04 (2007): 559. Web.

8. Su, Ching-Hua, Chi-Shu Sun, Sheng-Wei Juan, Hsiu-O Ho, Chung-Hong Hu, and Ming-Thau Sheu. “Development of Fungal Mycelia as Skin Substitutes: Effects on Wound Healing and Fibroblast.” Biomaterials20.1 (1999): 61-68. Web.

9. Chen, Miaw-Ling, and Bi-Fong Lin. “Effects of Triterpenoid-Rich Extracts of Ganoderma Tsugae on Airway Hyperreactivity and Th2 Responses in Vivo.” International Archives of Allergy and Immunology 143.1 (2007): 21-30. Web.